| ncRNA name | hsa-miR-24 |
| ncRNA Category | miRNA |
| Disease name | age-related cataract |
| Species | Homo sapiens |
| Tissues/Cell_line | anterior lens capsules; human lens epithelial cell line SRA01/04 |
| Methods | qRT-PCR, Western blot, cell viability assay, Caspase-3 activity assay, transfection, luciferase reporter assay |
| Expression pattern | up-regulated |
| Functional description | miR-24 evoked by oxidative stress enhances LEC apoptosis and inhibits LEC proliferation by directly targeting p53, also contributing to the development of cataracts.The p53 signaling pathway plays an important role in regulating the cell cycle and cell differentiation, promoting apoptosis, and activating cell death. |
| PubMed ID | 29393409 |
| Year | 2018 |
| Title | miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts. |
| Drug-related ncRNA | NO |
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